Nerlens Noel (right knee contusion) and Jerami Grant (right knee and quad contusion) will miss the Sixers' game tonight against the Hornets and Friday's return matchup in Charlotte.
Noel has missed the previous three games his injury. Grant left the loss to the reigning champion Warriors on Sunday in the first quarter.
Richaun Holmes (right Achilles strain) is also out Tuesday. He left Saturday's game against the Trail Blazers and did not play in Sunday's game.
"We have 10 players, 10 able bodies and it's going to be on me to really pay attention on how to sub that and play that," Sixers head coach Brett Brown said.
Brown will start Ish Smith, Isaiah Canaan, Hollis Thompson, Robert Covington and Carl Landry Tuesday night at the Wells Fargo Center.
The Sixers called Christian Wood up from the Delaware 87ers on Sunday to add to the shorthanded frontcourt.